ArborVita Associates
Research - Chicago, Illinois, United States
ArborVita Associates Employees
ArborVita Associates Details
AVA has created a Direct, Rapid and Precise (DRAP) way to modify the genomes of experimental animals or cells via homologous recombination utilizing a unique, recombinase isolated and cloned from Drosophila and small synthetic targeting DNAs. The process has been applied in three vertebrate species that include mice and pigs. The DRAP method is efficient and has advantages over competing technologies - principally because it modifies an endogenous locus without the need for large, complex DNA constructs or reliance upon viral vectors that insert randomly or require the insertion of foreign sequences in the genome. The DRAP method has potential for creating new animal models for drug development and testing, xenotransplantation as well as for clinical applications in humans.
