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ICE-Bioscience is a rapidly growing Chinese-based preclinical CRO specialized on in vitro and in vivo services. The company is especially experienced in the highly specialised electrophysiological field. We offer unique preclinical services in the ion channel pharmacology and safety assessments. We provide a flexible, high quality, efficiency service with low cost that meets the needs of a wide range of biopharmaceutical companies. Our services:Cardiac safety screening:hERG screening;Action Potential Duration (APD) Assessment ;Screening of QT-prolongation in Langendorff heart; Cardiac safety screening in unconscious rats Ion channel profiling:Voltage-gated ion channels---KV, CaV and NaV families; Other potassium channels---Kca, Inward rectifiers (e.g. Kir2.1) or Two-pore domain (e.g. TREK, TASK); Ligand-gated ion channels--- P2X and TRP families, Glutamate (NMDA, AMPA) and GABAA receptors; Other channels---CRAC and chloride channels (e.g. CFTR) In vitro high-throughput screening:Stable Cell Line Generation; GPCR Functional Assay; Protein Kinase Assay
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