Life Sciences Institute of New Jersey
Scientific Research - Belle Mead, NJ, US
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Contemporary Paradigm(s) in Medicine while having many positive dimensions do make an insidious impact on Humans as well as on Societal Healthcare and Socioeconomics. To meet these challenges Scientists, Professors and Members of the Global community of Universities, Enterprises and Research Institutions have joined cause in the restructured ‘Not for Profit' Life Sciences Institute of New Jersey (LSINJ) (Links 1 – 3). The Core Goal of the LSINJ is to initiate the restructuring of the fundamental paradigm of Medicine from post-mutational (pathological) therapeutic intervention to preemption in Real Time. The strategy in this undertaking at the LSINJ is based on a Combinatorial Approach (Links, Nallaseth, MOJPB, 2018) which melds 2 lynchpin but overlapping phases. The first Discovery Phase draws on Darwinian Natural Variation (DNV) in Chromosome/Genome Biology and Evolutionary Genetics of Speciation (EVS) to either screen for or to induce Genetic Lesions (mutations) in Interspecific Genomes as those which are of mechanistic and physiological relevance. Its underlying principles in interrogating unknown components in uncovering unknown products and processes is akin to any contemporary undertaking of similarly large dimensions. Including Saturation Mutagenesis and Next Generation Sequencing of genome(s), as well as Particle Beam Collision dependent discovery of novel Subatomic Particles in e.g. the Large Hadron Collidor. These Interspecific Genomes e.g. of mice are a comprehensive source of relevant mechanisms, molecules, and Genetic Networks inserting errors into the genome that constitute the Mutome. The second but overlapping Analytical Phase draws on the resolution and power of contemporary methods including OMICs, Optics, Cyborg assembly, Radio waves and Super-Computing Analyses. Together they will culminate in the Systematization, Surveillance and Control of Networks (molecules and mechanisms) of Genes Regulating and Maintaining Mammalian Genome Biology.
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