Biotechnology - Sainte-Hélène-du-Lac, Rhone-Alpes, France
Nanobiose's mission is to provide pharma, biotech and cosmetic companies with better tools to improve their in vitro analysis of efficacy / safety of drug candidates.Nanobiose develops SecretCells®, an innovative lab-on-a-chip system to evaluate secreted biomarkers from 2D or 3D perfused cells.SecretCells® combines a microfluidic biochip (where the perfused 3D cell cultures stand) and a removable biosensor for a multiplexed on-line biomarkers analysis.While better mimicking in vivo like conditions, SecretCells® allows more accurate and more predictive results for the evaluation of drug candidates at early stages.SecretCells® is a very flexible solution :- Any 2D/3D cell culture set up- Explants, spheroïds, organoïds, biopsies- Any cell exposure set up, from 1 to 24 hours- Customizable biosensor and reagents kits- Parallelize or serialize assaySecretCells® is easy-to-use :- Adaptable to existing lab equipment (fluorescence microsopes, incubators etc…)- Easy to manipulate with organizer tray- Open and accessible cell culture wells- Possibility to change biosensor without stopping the experimentPotential applications : - Efficacy/cytotoxicity assessment with reduced variability in the measures & better window (vs. 96-w plates)- Cytokines release studies- Study of exposure time vs doses effects- Co-cultures at a distance with intermediate biomarker assessment- Explants / biopsies SecretCells® is a unique patented tool to simultaneously assess the ability of the tested items to elicit / inhibit specific biomarkers responses and their cytotoxic potential. And much more.Contact us to know more : contact@nanobiose.com
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