Penn State Health St. Joseph is a non-profit network consisting of St. Joseph Medical Center, St. Joseph Downtown Reading Campus, St. Joseph Medical Group and St. Joseph Provider Hospital Organization (PHO). Founded in 1873 by the Sisters of St. Francis, the network provides a full-range of outpatient and inpatient diagnostic, medical and surgical services. The 380,000 sq. ft., 212-bed state-of-the-art hospital and health campus opened in late 2006 on 40 acres in Bern Township. In 2015, St. Joseph Regional Health Network was the first member to transition into Penn State Health, a newly-created non-profit entity of Penn State University.St. Joseph is nationally certified as a Center of Excellence in Chest Pain, Stroke and Heart Failure. St. Joseph has 16 Ambulatory Care Centers stretching from Elverson in Chester County through Berks County to the Schuylkill County border. The centers offer urgent care, imaging studies, lab work and other ambulatory services and procedures. St. Joseph's Downtown Reading Campus anchors the ambulatory network and is the largest primary care provider in the City of Reading, operating out of a thriving 266,000 square foot facility that provides family practice, women's and children's services and diagnostic services. St. Joseph Medical Group is a network of 80 physicians and mid-level providers. The group includes: specialists in Internal Medicine, Family Medicine, Hospitalists, Orthopedics and Sports Medicine, Gynecology and Obstetrics, Neurology, Neurosurgery, General Surgery, Women's Services and Vascular Surgery. St. Joseph also offers a family practice medical residency program, and provides clinical training for several nursing and allied health professionals. St. Joseph is fully accredited by the Joint Commission on Accreditation of Healthcare Organizations (JCAHO).

Family Medicine Diabetes Management Orthopedics and Sports Medicine Internal Medicine Accredited Stroke Center Cancer Center Urgent Cares Pediatrics/ NICU Neurosciences Prenatal Care Birthing Center Support Groups Heart Institute Vascular and Vein Center General Surgery Robotic-Assisted Surgery Women's Services Multidisciplinary Lung and Breast Clinics Laboratory Services Radiology Testing Infusion Services Wound Care Women's Services Hospital/Clinic Specialty Hospitals Except Psychiatric Hospital & Health Care