Research - Hatboro, Pennsylvania, United States
RAbD was a biotechnology company founded by Gregory Adams, Ph.D., Matthew Robinson, Ph.D. and Roland Dunbrack, Ph.D. that was focused on the knowledge-based design of biological agents that bind to key functional, often highly conserved and difficult to target antigenic epitopes or receptors. We used homology modeling, crystal structures, protein docking and design software and, in the case of antibody development, new algorithms to drive combinatorial sampling of CDRs to computationally design new antibodies and then express, validate and perform further design in an iterative manner.RAbD ceased operations due to a lack of sufficient funding that was necessary to demonstrate the viability of this design algorithms.