Youthereum Genetics Inc.
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Youthereum Genetics Inc. Details
At Youthereum, we are translating the paradigm of epigenetic rejuvenation by partial reprogramming into a therapy that would be able to slow down or, ideally, reverse aging. Our ultimate goal is to prevent or cure all age-related diseases such as cancer, heart disease and dementia by tackling their primary underlying cause — the aging process itself. To achieve our goal we are working to create a rejuvenating gene therapy that could radically extend the lives of pets and humans. The therapy would consist of two stages: first delivering the genes responsible for epigenetic rejuvenation into the body, where these genes would persist but be inactive by default, and then periodically activating them by a small molecule.Our approach is built upon the notion that aging is epigenetically controlled and therefore is potentially reversible. A number of studies have already demonstrated full reversibility of aging hallmarks by Yamanaka factors on a cellular level. One small step in this direction was made in 2016 by Ocampo et al., who demonstrated that Yamanaka factors can be safely used in vivo. Moreover, they showed that when these factors are induced in short bursts, such partial reprogramming leads to systemic physiological rejuvenation and life extension. Today, the giant leap for mankind is extending this rejuvenation from the cellular to organismal level. Building upon the above discoveries, we are trying to optimize the partial reprogramming approach so that it can be used therapeutically in a two-step gene therapy. In step 1, we envision delivering the genes responsible for epigenetic rejuvenation into the body, where these genes would persist but be inactive by default. In step 2, these genes would then be periodically activated by a small molecule, and would do the work of rolling back organismal epigenetics to a younger level, thereby decreasing the patient's biological age.
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