PREMIERE stands for PREdictive Modelling with QuantIfication of UncERtainty for MultiphasE Systems, an EPSRC grant (EP/T000414/1) to create an unprecedented impact in healthcare, energy and manufacturing sectors to drive economic growth. Collaboration between Imperial Collge London, University of Birmingham, University College London and the Alan Turing Institute.This programme is aimed at advancing machine learning, computational fluid dynamics and design of experiments to create ultra-fast predictive models. PREMIERE will address a wide spectrum of challenges that will result in a paradigm-shift in multiphase flow research worldwide.