Recruitment costs are rapidly becoming a larger and larger portion of the overall study budget. Research Answers produces results at a significantly lower subject acquisition costs. We address the root causes of poor enrollment and share best practices of top performing research sites. Our cross-functional approach includes the following:• Early intervention to help sites address recruitment issues before the study start-up.• Protocol validation testing to estimate how large a patient population must be to meet enrollment projections and identify "problem" entry criteria that would significantly reduce enrollment.• Monitor training on best practice recruitment processes.• Technology tools that will assist sites with EMR to query their databases to quickly identify potential subjects.• Follow-up site training with site after enrollment initiation to keep a consistent focus on enrollment.