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The research activities of the ISAC are concerned with many basic aspects of atmospheric physics, chemistry and biology, which are of applicative relevance in the field of environmental protection. The unit has been in operation for 25 years, focusing on the impact that climate and microclimate produce on cultural heritage and cultural landscape, including the identification of strategies for conservation and identification of environmental technology for the damage assessment and management of cultural assets both indoor and outdoor. In particular the unit studies the physical, chemical and biological mechanisms of damage, the effects of climate and microclimate on moveable and immoveable Cultural Heritage, including multi-pollutants, sea-salts and biological particles. The unit collaborates with various research institutes in Italy and Europe on environmental protection of cultural heritage, with public organisations responsible for the conservation of cultural heritage and with local authorities for indoor and outdoor damage assessments of cultural assets and it is involved in university teaching and professional training courses in the fields of Atmospheric Physics, Climate Change, Durability of Building Materials and Sustainable Protection of Cultural Heritage.