The Appalachia HIDTA mission is to use a multi-disciplinary approach to deal with the ongoing threats to public health and safety, particularly as it regards prescription drug diversion, the threat of heroin, as well as the continued threats of marijuana, cocaine, methamphetamine and synthetic drugs. The Appalachia region is arguably the epicenter of this crisis, and will require unprecedented multi-disciplined cooperation to effectively address the many faceted health and public safety problems that result from this daunting threat. The Appalachia HIDTA will serve as the conduit for this cooperation.