Frank Scheffler

Head of Business Development & Global Collaborations at Hypha Discovery Ltd - Uxbridge, ENG, UK

Frank Scheffler's Colleagues at Hypha Discovery Ltd
Vincent Poon

Recombinant Technologies Group Leader

Contact Vincent Poon

Frank Scheffler's Contact Details
HQ
Location
Hillingdon, England, United Kingdom
Company
Hypha Discovery Ltd
Frank Scheffler's Company Details
Hypha Discovery Ltd logo, Hypha Discovery Ltd contact details

Hypha Discovery Ltd

Uxbridge, ENG, UK • 20 - 49 Employees
Major Drugs

Hypha Discovery is a specialist CRO with expertise in scalable synthesis, purification and structure elucidation of phase 1 and phase 2 metabolites using biotransformation and late-stage chemical synthesis techniques. We work with pharma and agrochemical companies globally to make even the most difficult-to-synthesise metabolites. Hypha are experts in purification and structure elucidation of small molecules by NMR spectroscopy, as well as the production of microbial products. Synthesis of metabolites of drugs and agrochemicalsWe create human and other mammalian phase 1 and phase 2 metabolites of drug candidates and agrochemicals at mg to gram scale for many of the top pharma and agrochemical companies. Metabolites produced from a variety of phase I reactions are accessible, including both CYP and non-CYP derived mechanisms in addition to conjugated metabolites such as N-, O– & acyl glucuronides and sulfates. We employ a number of techniques in our One-Stop Metabolite Shop to identify the best method for synthesis and scale-up:• Chemical synthesis • Recombinant enzymes using PolyCYPs and other enzymes• Microbial biotransformation • Mammalian tissues such as liver fractions (S9/microsomes) We can provide an end-to-end service including purification, structure elucidation using NMR spectroscopy, and certificates of analysis.Late stage functionalisationMultiple oxidised derivatives of lead compounds can be accessed in parallel from application of the PolyCYPs enzyme platform and our new late-stage chemical oxidation platform. These techniques generate molecules that have increased polarity together with the possibility of greater activity, better selectivity or improved DMPK properties than the parent compound. The process provides an opportunity for expanding chemical space to generate SAR information or to identify derivatives with superior properties.

Metabolites for DMPK and environmental fate Lead diversification to create oxidised derivatives Contract fermentation purification and structure elucidation Natural product screening libraries Anti-microbial drug screening Late stage hydroxylation CYP metabolites Glucuronides and other conjugated metabolites Non-CYP metabolites Microbial natural products Small molecule purification Structure elucidation chemical synthesis Drug metabolites Environmental fate metabolites Metabolite kits Metabolite purification
Details about Hypha Discovery Ltd
Frequently Asked Questions about Frank Scheffler
Frank Scheffler currently works for Hypha Discovery Ltd.
Frank Scheffler's role at Hypha Discovery Ltd is Head of Business Development & Global Collaborations.
Frank Scheffler's email address is ***@hyphadiscovery.co.uk. To view Frank Scheffler's full email address, please signup to ConnectPlex.
Frank Scheffler works in the Major Drugs industry.
Frank Scheffler's colleagues at Hypha Discovery Ltd are Vincent Poon, Ravi Manohar, Gillian Charles, Jonathan Steele and others.
Frank Scheffler's phone number is
See more information about Frank Scheffler