BioResponse Nutrients, LLC is the originator and patent holder for microencapsulated Diindolylmethane. (BioResponse DIM). Our mission since 1998 has been our commitment to research the present nutraceutical and future therapeutic uses of DIM. Michael A. Zeligs, M.D., CEO and Founder, pioneered the commercialization of DIM and was the first to ever develop bioavailable microencapsulated diindolylmethane (DIM) for human use.