TwentyFive Main Cupcake Parlor and Cafe. TwentyFive Main is a family owned and operated gourmet café and cupcake parlor. Located in Historic Downtown St. George, UT. TwentyFive Main thrives off of its delectable menu and laid-back atmosphere. Their cupcakes are the most savory dessert in town and the art and live music make it a local hotspot. TwentyFive Main highlights art from local artists and they Rock Main most Friday nights as local musicians perform. Patrons love the chic décor and the ambiance is exactly what you would expect from a local hipsters café. Whether you are coming in for the locally grown coffee or full breakfast, lunch, and dinner menu TwentyFive Main will provide exceptional service and keep you coming back for more!