Olga Makarova's Colleagues at Creatv MicroTech, Inc.
Olga Makarova's Contact Details
(301) 983-1650
Creatv MicroTech, Inc.
Olga Makarova's Company Details
Creatv MicroTech's mission is to dramatically reduce global cancer mortality through early detection. Our innovative blood test can detect cancer in the earliest stages, even before symptoms. It can also confirm whether a patient is responding to treatment and surveil for early signs of recurrence after treatment has finished. Clinical application of this highly sensitive and specific test will improve cancer treatment outcomes. Cancer touches all of us. Almost 40% of Americans are currently expected to receive a diagnosis of cancer in their lifetime. Over half of these diagnoses occur after significant progression, in stages 3 and 4, making it difficult to achieve successful therapeutic outcomes. Early detection with high accuracy is needed for all major cancers. Nearly 14.5 million Americans are living with a history of cancer, many in remission under surveillance for possible recurrence. Early detection of recurrence enables faster response and improved outcomes. Our CellSieve diagnostic platform uncovered a previously unknown cell in the blood of cancer patients, the cancer associated macrophage-like cell (CAML). These cells are very large and distinctly different from normal cells and circulating tumor cells (CTCs). We found these CAMLs in patients with solid tumors, but not in healthy individuals. CAMLs are highly informative, because they contain markers of the cancer type and indicate sensitivity or resistance to particular treatments. Unlike CTCs, CAMLs are found in all stages of cancer, including stage I. Together, CAMLs and CTCs provide a unique capability for early detection of cancer, monitoring treatment, and watching for recurrence. CellSieve is currently in research use at leading cancer clinics in the US and eight foreign countries.