Pat McDonough's Colleagues at Vala Sciences Inc
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Vala Sciences Inc
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Vala Sciences helps researchers achieve an unrivaled in vitro understanding of how human cells respond to drug compounds.Vala is committed to providing expert services to pharmaceutical developers and researchers to help overcome the persistent challenge of reducing avoidable clinical failures of drug candidates in the following areas:Cardiac biology: By precisely measuring up to three channels (voltage, calcium, and contractility) of single-cell hiPSC-cardiomyocyte kinetic data in real time and comparing cell responses with known healthy or disease-model cells, Vala can help rank order drug candidates by identifying toxicities, dose response, and efficacy.Neuroscience: Vala has developed co-culture assays with hiPSC-neurons, -microglia, and -astrocytes for neurodegenerative disease drug discovery and toxicity screening. By measuring voltage and calcium kinetics, neurite and synapse formation, and engulfment by microglia, Vala can provide a detailed picture of disease mechanisms and treatment efficacy. Vala Sciences develops and manufactures the Kinetic Image Cytometer (KIC®) and Structured Illumination Microscopy (SIM) platforms, which enable information-rich measurements for making new insights into the cell biology of disease. CyteSeer®, our cell image analysis software, can resolve billions of single-cell data points from fixed or live cells. Vala's toolset allows researchers to perform accurate, cost-effective screens for drug candidates with high probability of clinical success and low probability of side effects. We provide varied and validated high content screening services that quantify the effects of compound libraries on a number of target molecules.