Established 1959, AO Research Institute Davos (ARI) aims to:• Contribute to high quality applied preclinical research and development (exploratory and translational) focused towards clinical applications/solutions.• Investigate and improve the performance of surgical procedures, devices, and substances.• Foster a close relationship with the AO medical community, academic societies, and universities.• Provide research environment/support for AO clinicians.All AO Research Institute Davos projects are applied preclinical research or applied preclinical development projects focused towards clinical applications. Definitions (within the applied research):• Exploratory applied preclinical research is fundamental research, to solve major clinical problems over an extended timeframe (over ten years).• Translational applied preclinical research aims at developing a clinical applicable result in around five years and builds upon the fundamental applied preclinical research. This research is usually not possible without the previous fundamental applied preclinical research.