Stephen Antonelli
Senior Director, Regulatory CMC at Cogent Biosciences - Waltham, Massachusetts, US
Stephen Antonelli's Colleagues at Cogent Biosciences
Elodie Rosinovsky
Sr Director, Head of CMC, Clinical Supply Chain and Program Management
Stephen Antonelli's Contact Details
(617) 945-5576
Boston, Massachusetts, United States
Cogent Biosciences
Stephen Antonelli's Company Details
Cogent Biosciences is a biotechnology company focused on developing novel precision therapies to treat a broad range of patients with unmet medical needs. Cogent’s lead program, bezuclastinib, is designed to selectively and potently inhibit exon 17 mutations found within the KIT receptor tyrosine kinase, including KIT D816V. KIT D816V is responsible for driving a rare and serious condition called Systemic Mastocytosis, and exon 17 mutations are also found in patients with advanced gastrointestinal stromal tumors (GIST), a type of cancer with strong dependence on oncogenic KIT signaling. Bezuclastinib has already exhibited promising early clinical activity and safety in a Phase 1/2 trial in patients with advanced GIST and also has the potential to fill an unmet need for patients living with Systemic Mastocytosis.